Scientific Rigor Research Articles

Emerging technologies in citizen science and potential for insect monitoring.

Emerging technologies are increasingly employed in environmental citizen science projects. This integration offers benefits and opportunities for scientists and participants alike. Citizen science can support large-scale, long-term monitoring of species occurrences, behaviour and interactions. At the same time, technologies can foster participant engagement, regardless of pre-existing taxonomic expertise or experience, and permit new types of data to be collected. Yet, technologies may also create challenges by potentially increasing financial costs, necessitating technological expertise or demanding training of participants. Technology could also reduce people's direct involvement and engagement with nature. In this perspective, we discuss how current technologies have spurred an increase in citizen science projects and how the implementation of emerging technologies in citizen science may enhance scientific impact and public engagement. We show how technology can act as (i) a facilitator of current citizen science and monitoring efforts, (ii) an enabler of new research opportunities, and (iii) a transformer of science, policy and public participation, but could also become (iv) an inhibitor of participation, equity and scientific rigour. Technology is developing fast and promises to provide many exciting opportunities for citizen science and insect monitoring, but while we seize these opportunities, we must remain vigilant against potential risks. This article is part of the theme issue 'Towards a toolkit for global insect biodiversity monitoring'.

Language-adaptive artificial intelligence: assessing CHATGPT'S answer to frequently asked questions on total hip arthroplasty questions.

ChatGPT is reported to be an acceptable tool to answer a majority of frequently asked patient questions. ChatGPT also converses in other languages including Urdu, which offers immense potential for the education of Pakistani patients. Therefore, this study evaluated ChatGPT's Urdu answers to the ten most frequently asked questions on Total Hip Arthroplasty, which were then rated by an expert. Out of 10 answers in English, 9 (90%) were satisfactory requiring minimal clarification and 1 (10%) was satisfactory requiring moderate clarification. In both Roman and Nastaliq script Urdu, 1 (10%) answer was satisfactory requiring moderate clarification, while 9 (90%) were unsatisfactory requiring substantial clarification. In conclusion, as opposed to ChatGPT English responses, Urdu responses were much less rigorous, generic, and lacked scientific rigor. We have a long way to go before Pakistani patients with limited English language skills could benefit from AI chatbots like ChatGPT.

Thank You to Our 2023 Reviewers

AbstractOn behalf of the journal, AGU, and the scientific community, we, the editors of Earth's Future, are delighted to publish the names of the 817 peer reviewers who provided 1,242 reviews for our journal in 2023 (italicized names have contributed three or more reviews). Your diligent efforts to provide timely comments on our submissions have significantly improved the manuscripts and elevated the scientific rigor of future research. As a unique transdisciplinary journal, Earth's Future delves into the state of the planet and its inhabitants, sustainable and resilient societies, the science of the Anthropocene, and predictions of our shared future through research articles, reviews, and commentaries. In the face of observed and anticipated global environmental and climatic changes, the need for high‐quality scientific theories, assessments, and projections about the future of our planet has never been more pressing. To safeguard research integrity in this crucial area, we rely on our reviewers' expertise and selfless cooperation. We extend our heartfelt thanks to each of the individuals listed below for their contributions to our journal and the broader scientific discourse. Your dedication is immensely appreciated.

Advancing data honesty in experimental biology.

The ease with which scientific data, particularly certain types of raw data in experimental biology, can be fabricated without trace begs urgent attention. This is thought to be a widespread problem across the academic world, where published results are the major currency, incentivizing publication of (usually positive) results at the cost of lax scientific rigor and even fraudulent data. Although solutions to improve data sharing and methodological transparency are increasingly being implemented, the inability to detect dishonesty within raw data remains an inherent flaw in the way in which we judge research. We therefore propose that one solution would be the development of a non-modifiable raw data format that could be published alongside scientific results; a format that would enable data authentication from the earliest stages of experimental data collection. A further extension of this tool could allow changes to the initial original version to be tracked, so every reviewer and reader could follow the logical footsteps of the author and detect unintentional errors or intentional manipulations of the data. Were such a tool to be developed, we would not advocate its use as a prerequisite for journal submission; rather, we envisage that authors would be given the option to provide such authentication. Only authors who did not manipulate or fabricate their data can provide the original data without risking discovery, so the mere choice to do so already increases their credibility (much like 'honest signaling' in animals). We strongly believe that such a tool would enhance data honesty and encourage more reliable science.

Economic Fraud and Associated Risks: An Integrated Bibliometric Analysis Approach

This study offers a comprehensive insight into the realms of economic fraud and risk management, underscoring the necessity of adaptability to evolving technologies and shifts in financial market dynamics. Through the application of bibliometric methodologies, this study meticulously maps the relevant literature, delineating influential works, notable authors, collaborative networks, and emerging trends. It reviews key research contributions within the field, alongside reputable journals and institutions engaged in academic research. The examination highlights the logical, conceptual, and social interconnections that define the landscape of economic fraud and associated risks, elucidating how these findings inform the understanding, mitigating, and combating of the risk of fraud. Our bibliometric analysis methodology is grounded in the utilization of the Scopus database, employing rigorous filtering and extraction processes to obtain a substantial corpus of pertinent articles. Through a fusion of performance analysis and science mapping, our investigation elucidates central themes and visually represents the interrelationships between studies. Our research outcomes underscore the frequency of paper publications across diverse regions, with particular emphasis on the predominant scientific output from the US and China. Additionally, trends in academic citations are identified, indicative of the significant impact of papers on academic research and the formulation of public policies. By means of bibliometric analysis, this study not only consolidates existing knowledge but also catalyzes the exploration of future research trajectories, emphasizing the imperative of addressing these issues with heightened scientific rigor.

First-line immunotherapy efficacy in advanced squamous non-small cell lung cancer with PD-L1 expression ≥50%: a network meta-analysis of randomized controlled trials

ObjectiveThe optimal first-line immunotherapy regimen for patients with PD-L1 expression ≥50% in squamous non-small cell lung cancer (Sq-NSCLC) remains uncertain. This study utilized net-work meta-analysis (NMA) to indirectly compare the efficacy of various first-line immuno-therapy regimens in this patient subset.MethodsSystematic searches were conducted across PubMed, the Cochrane Library, Web of Science, and Embase databases for randomized controlled trials reporting overall survival (OS) and progression-free survival (PFS) outcomes. The search spanned from database inception to November 3, 2023. Bayesian network meta-analysis was employed for a comprehen-sive analysis. To ensure scientific rigor and transparency, this study is registered in the Interna-tional Prospective Register of Systematic Reviews (PROSPERO) under the registration number CRD42022349712.ResultsThe NMA encompassed 9 randomized controlled trials (RCTs), involving 2170 patients and investigating 9 distinct immunotherapy regimens. For OS, the combination of camrelizumab and chemotherapy demonstrated the highest probability (36.68%) of efficacy, fol-lowed by cemiplimab (33.86%) and atezolizumab plus chemotherapy (23.87%). Regarding PFS, the camrelizumab and chemotherapy combination had the highest probability (39.70%) of efficacy, followed by pembrolizumab (22.88%) and pembrolizumab plus chemotherapy (17.69%). Compared to chemotherapy, first-line treatment with immune checkpoint inhibitors (ICIs) in Sq-NSCLC pa-tients exhibited significant improvements in OS (HR 0.59, 95% CI 0.47-0.75) and PFS (HR 0.44, 95% CI 0.37-0.52).ConclusionThis study suggests that, for Sq-NSCLC patients with PD-L1 expression ≥50%, the first-line immunotherapy regimen of camrelizumab plus chemotherapy provides superior OS and PFS outcomes. Furthermore, ICIs demonstrate enhanced efficacy compared to chemotherapy in this patient population.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD 42022349712.

Rigid frameworks or flexible approaches? The debate on employee engagement measurement in organisational contexts

Purpose This strategic commentary aims to examine the benefits and drawbacks of rigid frameworks versus flexible approaches to measuring employee engagement, arguing for a hybrid model that incorporates the best of both to better correspond with organisational subtleties and strategic goals. Design/methodology/approach This study compares the standardised, benchmarking capabilities of inflexible frameworks such as Gallup’s Q12 to the adaptability and customisation potential of flexible approaches. It emphasises the creation and implementation of a hybrid methodology that preserves the integrity of engagement measurement while also incorporating organisational-specific insights. Findings Despite their different benefits, rigid frameworks may neglect distinct organisational cultures, whereas completely flexible techniques may suffer with measuring consistency. A hybrid model, which combines core standardised questions and unique items, provides a balanced solution for improving the relevance, actionability and reliability of engagement data across dynamic organisational landscapes. Originality/value The discussion culminates with the proposal of a hybrid measurement strategy as a strategic innovation in human resource management. By combining scientific rigour and contextual sensitivity, this model provides a nuanced roadmap for organisations looking to thoroughly understand and effectively negotiate the complexity of employee engagement in an evolving work environment.

Post-radiotherapy stage III/IV non-small cell lung cancer radiomics research: a systematic review and comparison of CLEAR and RQS frameworks.

Lung cancer, the second most common cancer, presents persistently dismal prognoses. Radiomics, a promising field, aims to provide novel imaging biomarkers to improve outcomes. However, clinical translation faces reproducibility challenges, despite efforts to address them with quality scoring tools. This study had two objectives: 1) identify radiomics biomarkers in post-radiotherapy stage III/IV nonsmall cell lung cancer (NSCLC) patients, 2) evaluate research quality using the CLEAR (CheckList_for_EvaluAtion_of_Radiomics_research), RQS (Radiomics_Quality_Score) frameworks, and formulate an amalgamated CLEAR-RQS tool to enhance scientific rigor. A systematic literature review (Jun-Aug 2023, MEDLINE/PubMed/SCOPUS) was conducted concerning stage III/IV NSCLC, radiotherapy, and radiomic features (RF). Extracted data included study design particulars, such as sample size, radiotherapy/CT technique, selected RFs, and endpoints. CLEAR and RQS were merged into a CLEAR-RQS checklist. Three readers appraised articles utilizing CLEAR, RQS, and CLEAR-RQS metrics. Out of 871 articles, 11 met the inclusion/exclusion criteria. The Median cohort size was 91 (range: 10-337) with 9 studies being single-center. No common RF were identified. The merged CLEAR-RQS checklist comprised 61 items. Most unreported items were within CLEAR's "methods" and "open-source," and within RQS's "phantom-calibration," "registry-enrolled prospective-trial-design," and "cost-effective-analysis" sections. No study scored above 50% on RQS. Median CLEAR scores were 55.74% (32.33/58 points), and for RQS, 17.59% (6.3/36 points). CLEAR-RQS article ranking fell between CLEAR and RQS and aligned with CLEAR. Radiomics research in post-radiotherapy stage III/IV NSCLC exhibits variability and frequently low-quality reporting. The formulated CLEAR-RQS checklist may facilitate education and holds promise for enhancing radiomics research quality. Current radiomics research in the field of stage III/IV postradiotherapy NSCLC is heterogenous, lacking reproducibility, with no identified imaging biomarker. Radiomics research quality assessment tools may enhance scientific rigor and thereby facilitate radiomics translation into clinical practice.

Upgrading the Paradigm of Leadership Analysis

Abstract Leadership analysis has been a traditional paradigm for studying international relations. The theory of moral realism improves this paradigm’s scientific rigour when explaining the relationship between the leadership of major powers and system-level international changes. Methodologically, moral realism uses morality as the criterion to categorise international leadership, the key independent variable. The theory is developed to improve realism’s explanatory power regarding the common historical phenomenon of the rise and fall of great powers. Rather than being Sino-centric, the foreign policy recommendations extrapolated from the theory of moral realism—which are descriptive rather than prescriptive—are applicable to both China and other major powers. Since theories of systemic analysis have failed to explain the transition of global order from globalisation to the counter-globalisation, the paradigm of leadership analysis is worth consideration. It may indeed provide a vector of enquiry regarding the correlation between the current prevalence of populist leadership in major powers and the growing counter-globalisation trend.

[Interpretation of specification for service of cancer screening for workers].

As the backbone force of China's social and economic construction, the health status of workers is closely related to the nation's productivity and social development. Currently, cancers have become one of the major diseases threatening the health of workers. However, there are still many shortcomings in the cancer screening services for the workers. To standardize cancer screening services for workers, ensure the quality of screening services, and improve the overall screening effectiveness, 19 institutions, including Peking Union Medical College Hospital of the Chinese Academy of Medical Sciences, have jointly formulated the Group Standard "Specification for service of cancer screening for workers (T/CHAA 023-2023)". This standard follows the principles of "legality, scientific rigor, advancement, and feasibility" and combines the frontier scientific advances in cancer screening. It clarifies the relevant requirements for service principles, service design, service delivery, service management, service evaluation, and improving worker cancer screening. Implementing this group standard will help connect the common screening needs of workers, employers, and cancer screening service providers, standardize the screening process, improve screening quality, and ultimately increase the early diagnosis rate and survival rate of cancer patients. Consequently, this group standard will help safeguard workers' health rights and interests, ensure the labor force resources, promote the comprehensive coordinated and sustainable development of society, and contribute to realizing the "Healthy China 2030" strategic policy.

BiodiverseCity St. Louis—An Initiative of the Missouri Botanical Garden

Botanical gardens are addressing urgent biodiversity issues through plant-based capacities including botanical research and data-sharing, conservation horticulture, ecological restoration, seed banking, and more. The Missouri Botanical Garden initiative BiodiverseCity St. Louis, led by the Garden’s sustainability division, adds broad community engagement to this mix. This work includes public and professional education, the demonstration and promotion of ecological landscaping and Green Infrastructure practices, citizen science programs, and coordinating communications for a regional network of partner organizations focused on biodiversity. Diverse activity engages businesses, local governments, elementary and secondary (K-12) schools, colleges, and community groups. Community biodiversity work at the Garden is informed by an institutional core of scientific rigor, provides opportunity for internal collaborations, and aligns with global strategies for plant conservation—to ground impactful local work. Missouri Botanical Garden’s experience offers a model for public gardens: leveraging modes of community engagement, in concert with diverse institutional strengths, to address biodiversity needs.

Catalyzing communities of research rigor champions

Abstract The biomedical sciences must maintain and enhance a research culture that prioritizes rigor and transparency. The United States National Institute of Neurological Disorders and Stroke (NINDS) convened a workshop “Catalyzing Communities of Research Rigor Champions” that brought together a diverse group of leaders in promoting research rigor and transparency (identified as “rigor champions”) to discuss strategies, barriers, and resources for catalyzing technical, cultural, and educational changes in the biomedical sciences. This article summarizes two days of panels and discussions and provides an overview of critical barriers to research rigor, perspectives behind reform initiatives, and considerations for stakeholders across science. Additionally, we describe applications of network science to foster, maintain, and expand cultural changes related to scientific rigor and opportunities to embed rigorous practices into didactic courses, training experiences, and degree program requirements. We hope this piece provides a primer for the wider research community on current discussions and actions and inspires individuals to build, join, or expand collaborative networks within their own institutions that prioritize rigorous research practices.

ADVANCING HEALTHCARE DATA SOLUTIONS: COMPARATIVE ANALYSIS OF BUSINESS AND RESEARCH MODELS IN THE U.S

In the dynamic landscape of healthcare, data-driven solutions play a pivotal role in enhancing patient outcomes, optimizing processes, and steering strategic decision-making. This review presents a comprehensive comparative analysis of the business and research models underpinning healthcare data solutions in the United States. By examining the distinctive characteristics, challenges, and advancements within these models, this study aims to elucidate critical insights for stakeholders navigating the complex intersection of healthcare and data analytics. The American healthcare ecosystem is marked by a diverse array of entities engaged in harnessing data for various purposes, ranging from improving patient care to driving operational efficiencies. This analysis delves into the contrasting approaches adopted by businesses and research institutions in leveraging healthcare data. Businesses predominantly focus on profit-driven initiatives, emphasizing efficiency, scalability, and commercial viability. In contrast, research models prioritize scientific rigor, innovation, and academic collaboration, often with a primary focus on advancing medical knowledge. Key components of the comparative analysis include examining the regulatory frameworks governing healthcare data, the utilization of cutting-edge technologies such as artificial intelligence and machine learning, and the ethical considerations surrounding data privacy and security. Furthermore, this study investigates the impact of socioeconomic factors, such as disparities in access to healthcare and disparities in data availability, on the development and implementation of data solutions. The comparative analysis also highlights notable case studies and best practices from both business and research sectors, illustrating successful approaches to overcoming common challenges and driving innovation in healthcare data solutions. Additionally, emerging trends, such as the integration of wearables and Internet of Things (IoT) devices, are explored for their potential to revolutionize data collection and analysis in healthcare settings. Ultimately, this review underscores the imperative for collaborative efforts between business entities and research institutions to harness the full potential of healthcare data solutions, fostering advancements that benefit patients, providers, and society at large.
 Keywords:  Healthcare Data Solutions, Comparative Analysis, Business Models, Research Models, United States, Innovation.

Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion.

Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of diseases.

Assessment of transparency indicators in space medicine.

Space medicine is a vital discipline with often time-intensive and costly projects and constrained opportunities for studying various elements such as space missions, astronauts, and simulated environments. Moreover, private interests gain increasing influence in this discipline. In scientific disciplines with these features, transparent and rigorous methods are essential. Here, we undertook an evaluation of transparency indicators in publications within the field of space medicine. A meta-epidemiological assessment of PubMed Central Open Access (PMC OA) eligible articles within the field of space medicine was performed for prevalence of code sharing, data sharing, pre-registration, conflicts of interest, and funding. Text mining was performed with the rtransparent text mining algorithms with manual validation of 200 random articles to obtain corrected estimates. Across 1215 included articles, 39 (3%) shared code, 258 (21%) shared data, 10 (1%) were registered, 110 (90%) contained a conflict-of-interest statement, and 1141 (93%) included a funding statement. After manual validation, the corrected estimates for code sharing, data sharing, and registration were 5%, 27%, and 1%, respectively. Data sharing was 32% when limited to original articles and highest in space/parabolic flights (46%). Overall, across space medicine we observed modest rates of data sharing, rare sharing of code and almost non-existent protocol registration. Enhancing transparency in space medicine research is imperative for safeguarding its scientific rigor and reproducibility.

Post-modernization Paradigm on the Modern Cultural Communication Research: A Literature Review

The aim of this research study was to examine the patterns of cultural communication in the modern era and analyze its impact from a post-modernization paradigm. A rapid review approach employing the keywords “communication” AND “culture” AND “modern” was used to identify relevant articles published between 2019 and 2023. The reveiw which followed the PRISMA guidelines selected 35 articles that were grouped by type, function and purpose of communication (communication, identity, perception, education and entertainment) using the NVivo 12 Pro program. Most articles (n=13) were published in 2022 by predominantly authors from Russia. Modernization gives rise to cultural evolution and changes in ethnic and symbolic identities which drive post-modernists to advocate for the return of cultural identity that relies on various forms of communication. Modernization in cultural communication must be balanced with the post-modernization paradigm so that limitations in the generalization of communication design are in alignment with the subjective needs of each individual. The current study also acknowledged its methodological limitaons and potential biases for transparency and scientific rigor.

The 24th International Seaweed Symposium - ‘Seaweeds in a changing world’

AbstractThe 24th edition of the International Seaweed Symposium (ISS), an academic-industry event that dates back to 1952, was held for the first time in Oceania. The local organizing committee chaired by Professor Catriona Hurd, Institute for Marine and Antarctic Studies, University of Tasmania, and Professor Michael A. Borowitzka, Murdoch University, Western Australia worked tirelessly to curate a program that balanced scientific rigor with engaging discussions, providing ample opportunities for networking and collaboration. “Seaweeds in a changing world” was the theme of this symposium, participants from 48 countries from all over the world attended this symposium from 19-24 February 2023. More than 576 on-site and 207 virtual participants registered for the Symposium who contributed to the success of this event. The International Seaweed Association (ISA) ensures the continued development of seaweed and its benefits and serves as a bridge between research academia and industry. The ISA is ready to celebrate the Silver Jubilee of the ISS and is also proud to announce that the 25th International Seaweed Symposium (ISS) will be held in Victoria, British Columbia, Canada, 4-9 May, 2025 with the Local support of Ocean Networks Canada, Cascadia Seaweed, and the Pacific Seaweed Industry Association (https://iss25.com).

Assessment of heavy metals and fungi contamination of spices available in Saudi Arabian food cuisines

The study investigates the elemental composition and fungal contamination of commonly utilized spices and herbs, namely Turmeric, Cloves, Black pepper, Latency/cumin, Ring/legume, Cinnamon, Coriander, Ginger, Indian saffron, Fenugreek, Fennel flower, Aniseed, and Cayenne pepper. The presence of minerals and poisons elements, including zinc (Zn), iron (Fe), chromium (Cr), manganese (Mn), copper (Cu), nickel (Ni), cadmium (Cd), and lead (Pb), was examined. The concentration of the poisonous elements ranged from 44.1 ± 1.3 to 231±41 µgg−1 for Fe, 3.8 ± 5.9 to 17.3 ± 3.1 µgg−1 for Zn, 1.3 ± 0.2 to 9.3 ± 0.4 µgg−1 for Cu, 10.4 ± 1.1 µgg−1 for Mn, and 219±2.1 µgg−1 for Pb; Cd was below the level of detection. The study also assessed fungal contamination, revealing black pepper as the most contaminated sample (87.6 %), followed by saffron (76.2 %), Cayenne pepper (72.1 %), Coriander (65.0 %), and cumin (64.4 %). Conversely, fenugreek (52.5 %) and cinnamon (51.6 %) exhibited lower contamination rates. Aspergillus flavus was predominant in white pepper (70.0 %) and black pepper (34.0 %), while ginger showed a diverse range of fungal species, including A. niger, A. flavus, and Rhizopus stolonifera (50 %). Notably, cinnamon was found highly contaminated with Aspergillus flavus (40 %), Aspergillus niger (40 %), and Rhizopus stolonifera (40 %), while legumes were contaminated with Aspergillus niger (40 %), Penicillium arenicola (40 %), and Penicillium oxalicum (40 %). This study highlights potential health risks associated with spice consumption, particularly in large quantities, due to mycotoxin contamination. The findings emphasize the importance of monitoring and implementing stringent quality control measures in the spice industry to ensure food safety and mitigate health hazards associated with elemental and fungal contamination. By combining scientific rigor with a focus on local context, this research strives to make a meaningful impact on public health, culinary traditions, and the broader global conversation on food safety.

Thank You to Our 2023 Reviewers

AbstractThe entire editorial board of the Journal of Geophysical Research‐Solid Earth would like to sincerely thank all our colleagues who reviewed manuscripts for us in 2023. The hours they spent reading in order to provide insightful comments on manuscripts not only help improve the quality of these manuscripts but also ensure the scientific rigor of our reviewing process and eventually, of the research published in the field of Solid Earth Geophysics by our journal. With the advent of open science and AGU's data policy, the reviewing process now also encompasses checking the accessibility and availability of data and developed software. This is a key objective of AGU's FAIR (Findable, Accessible, Interoperable and Reusable) policy, for which many reviewers have provided suggestions that helped to improve the data presentation and availability, and which also fed the editorial board's reflection on the matter. Of course, we particularly appreciate timely reviews, particularly in light of the growing demands imposed by the increase of manuscripts submitted to Journal of Geophysical Research‐Solid Earth. We received 1,869 submissions in 2023, and 1,472 reviewers contributed to their evaluation by providing 2,237 reviews in total. We are deeply thankful for all of their contributions. The editorial board of Journal of Geophysical Research‐Solid Earth: Rachel Abercrombie, Yves Bernabé, Michael Bostock (former editor), Mark Dekkers, Anke Friedrich, Shin‐Chan Han, Satoshi Ide, Isabelle Manighetti (former EIC), Fenglin Niu, Douglas R. Schmitt, Alexandre Schubnel (EIC), Jun Tsuchiya, and all the associate editors of JGR‐SE.

UNRAVELING THE COMPLEXITIES OF CARDIOVASCULAR MEDICINE: A CONVERSATION WITH DR. PETER MCCULLOUGH (PT-BR VERSION)

Background: This interview covers Dr. Peter McCullough's medical career, experience as an editor of medical journals, and his expertise in areas such as cardiomyopathy, myocarditis, and pericarditis. Aims: The primary aim is to understand Dr. McCullough's perspectives on various medical topics, including his journey as a cardiologist, the importance of peer review, the phenomenon of Pheidippides cardiomyopathy, the differences between myocarditis and pericarditis, and the significance of ethical principles like the Nuremberg Code and the Declaration of Helsinki. Additionally, the interview aims to explore his concerns about censorship during the COVID-19 pandemic. Methods: The interview follows a question-and-answer format, with the interviewer posing questions to Dr. McCullough on various topics related to his medical career, research interests, and ethical considerations. Results: Dr. McCullough shares his insights on topics such as cardiomyopathy, myocarditis, and pericarditis, emphasizing the importance of peer review, identifying potential biases, and balancing scientific rigor with timely dissemination of findings. He also highlights the significance of the Nuremberg Code and the Declaration of Helsinki in ensuring informed consent and preventing coercion in medical research and treatment. Discussion: Dr. McCullough expresses concerns about censorship during the COVID-19 pandemic, which he believes impacted the ability of medical professionals to freely discuss and disseminate health-related information. He also discusses the potential role of COVID-19 vaccines in causing myocarditis and the need for transparent communication about treatment options and potential complications. Conclusion: The interview provides valuable insights from Dr. McCullough's extensive medical experience and expertise, covering a range of topics from cardiovascular conditions to ethical principles and the challenges posed by censorship during the COVID-19 pandemic.